|Tel||+44 (0)1865 223450|
- Centre for Statistics in Medicine Research Group
- Oxford Clinical Trials Research Unit Research Group
- Surgical Interventions Trials Unit Research Group
- ACL SNNAP Research Group
- TOPKAT Research Group
- CSAW Research Group
- NInjA Research Group
- WHITE FOUR Research Group
- DRAFFT 2 Research Group
- Bioyarn Trial Research Group
- PARCS Research Group
- NDORMS University Lecturer
Expertise in clinical trials, especially those involving surgery
Jonathan’s main research interest is in the design, conduct, analysis and reporting of randomised controlled trials, particularly surgical trials. His specific areas of interest include the specification of the target difference in the sample size calculation, addressing interventional expertise and methods for improving recruitment. Jonathan has extensive experience in systematic reviews of randomised controlled trials and diagnostic research. He has collaborated on numerous projects, including randomised trials, observational and diagnostic studies, methodological projects and systematic reviews in a variety of clinical areas, such as anaesthesia, cardiovascular research, obstetrics and gynaecology, ophthalmology, orthopaedics, primary care, general surgery and urology.
His current projects include CSAW, eTHoS, DELTA2, DRAFFT2, OPEN, PARCS, MACRO, ACHE and TOPKAT. Jonathan is the lead investigator of the DELTA2 and PACRCS projects. He works with the Oxford Clinical Trials Research Unit (OCTRU) and is a Deputy Director of the Surgical Intervention Trials Unit (SITU). Jonathan supervises a number of postgraduate students based both in Oxford and elsewhere on topics related to trials methodology.
Jonathan graduated from the University of Aberdeen with a BSc in Statistics. He undertook a PhD on the statistical assessment of learning curve effects in randomised controlled trials. Subsequently, he worked at the Health Services Research Unit, University of Aberdeen as a statistician. In August 2007, he started an MRC UK Fellowship focusing on methodology related to the design, conduct and analysis of surgical randomised trials. As part of this fellowship, he spent 12 months working at the Ottawa Hospital Research Institute in Canada before returned to the Health Services Research Unit in August 2009 to take up a position as a methodologist. In 2011, he was awarded an MRC UK Methodology Fellowship focusing on expertise-based trial designs and in August 2012 became a Senior Research Fellow. He joined the Centre for Statistics in Medicine (CSM) in 2013 on a secondment, during which he was appointed to a University Lectureship in NDORMS, University of Oxford.
Jonathan holds a number of external responsibilities. He serves on and chairs Data Monitoring and Steering committees for a number of clinical trials and is an associate editor of Clinical Trials, a member of the Editorial Board of BMC Trials and a statistical consultant for the British Journal of Surgery. Other responsibilities include serving on grant funding committees (e.g., for the NIHR's Health Technology Assessment and Research for Patient Benefit programmes) and membership of the IDEAL collaboration's steering group and of the ConDucT-II MRC Hub for Trials Methodology Research. He has over 100 journal article publications, including more than 30 as first or senior author.
Cook JA. et al, (2014), Health Technol Assess, 18, v - 175
IDEAL framework for surgical innovation 3: randomised controlled trials in the assessment stage and evaluations in the long term study stage.
Cook JA. et al, (2013), BMJ, 346
Cook JA., (2009), Trials, 10
Cook JA. et al, (2004), Clin Trials, 1, 421 - 427
Watson AJ. et al, (2016), Lancet
Hislop J. et al, (2014), PLoS Med, 11
Blencowe NS. et al, (2017), Clin Trials, 14, 211 - 218
Ranstam J. and Cook JA., (2017), British Journal of Surgery, 104, 442 - 442
Cook JA. and Ranstam J., (2017), British Journal of Surgery, 104, 97 - 97
Wartolowska K. et al, (2016), Trials, 17, 589 - 589
Cook JA. and Ranstam J., (2016), British Journal of Surgery, 103, 1814 - 1814
Ranstam J. et al, (2016), Br J Surg, 103