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BSc, MSc, MSc(Res), GradStat
Applied statistician striving for excellence in healthcare research
My responsibilities include advising on study design, providing written statistical input to project related documents such as the protocol and the grant application, preparing statistical analysis plans, undertaking statistical analyses and writing relevant sections of any dissemination material. My portfolio consists of clinical trials of different phases in a variety of fields, such as cancer, dementia and cardiovascular research, and methodological research aiming to improve the way we do medical research. Some of my current projects are ELAD (a multi-centre RCT assessing the effectiveness of liraglutide on Alzheimer’s patients), OnlineCBT (a trial assessing whether online Cognitive Behavioural Therapy improves mood and other key outcomes in people caring for individuals with dementia), TEPHRA (a trial of exercise to prevent hypertension in young adults) and OxVALVE (an observational study examining the epidemiology of valvular heart disease in the Oxfordshire population). My methodological interests include propensity score analysis and missing data.
I have a passion for Bayesian statistics and a growing interest in adaptive designs for clinical trials, such as the Time to Event Continual Reassessment Method (TiTE-CRM). I am involved in designing CSM’s first TiTE-CRM trial, CHARIOT, a phase I dose-finding trial on patients with oesophageal cancer.
I serve as an independent statistician on a Data Monitoring and Safety Committee (DSMC), where I provide independent support and advice to the trial’s data collection and safety information.
I am a Fellow of the Royal Statistical Society (RSS) and was appointed a GradStat in January 2015. I serve as the secretary of the Oxford Local Group of the RSS, where I am involved in organising an annual programme of events and lectures on statistical topics aiming to bring together anyone with an interest in statistics in Oxfordshire and the surrounding areas.
I obtained my BSc in Mathematics and Statistics from the University of Manchester in 2008, followed by an MSc in Applied Statistics (2009) and an MSc by Research (2013), both from the University of Oxford. My MSc by Research thesis is entitled “Bayesian Methods for Fine Mapping in Genetic Association Studies”. I joined CSM in August 2013.
Large-scale community echocardiographic screening reveals a major burden of undiagnosed valvular heart disease in older people: the
OxVALVE Population Cohort Study
d'Arcy JL. et al, European Heart Journal
Hopewell S. et al, (2016), BMC Medicine
Investigating the Impact of Missing Confounders in Propensity Score Analyses of Treatment Effects
Frangou E. and Collins G., (2016)
Domingo E. et al, (2016), Lancet Gastroenterology and Hepatology
Wain LV. et al, (2015), Lancet Respir Med, 3, 769 - 781
Simmons R. et al, (2012), J Infect Dis, 205, 1816 - 1820