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CORKA: Community based Rehabilitation after Knee Arthroplasty

CorkaCORKA is a prospective individually randomised controlled trial with blinded outcome assessment. It investigates whether patients with a knee replacement do better on a multi-component rehabilitation programme than usual care on.

Susan Dutton, Gary Collins and Michael Maia Schlüssel

PATH-2: Platelet rich plasma in achilles tendon healing

PATH2 logoPATH-2 is a pragmatic multi-centre, blinded, randomised placebo-controlled trial. It compares a platelet-rich plasma injection (PRP) with a placebo (imitation) injection in adults with Achilles tendon rupture.

Susan Dutton and Michael Maia Schlüssel

RIDD: Repurposing anti-TNF for treating Dupuytren’s disease

RIDD logoIn Dupuytren’s disease, nodules appear on the fingers and the fingers gradually curl towards the palm. Hand function is eventually significantly impaired. Currently, the disease is left to progress until the finger deformity is severe enough to warrant a surgical procedure in hospital.  

The RIDD trial tests whether the progression of Dupuytren’s disease can be halted or slowed by treatment with anti-TNF injection. If successful, anti-TNF treatment would prevent loss of hand function and the need for surgery, and would allow patients to be treated conveniently and quickly.

Susan Dutton and Bethan Copsey


Sujin Kang is collaborating on a number of studies on knee replacements. For example:

  • The effect of self-reported comorbidities on the Oxford Knee Score following primary total knee replacement
  • The influence of age on the patient-reported outcome of total knee arthroplasty in the UK 
  • Postoperative outcomes for patients managed according to the OERP for unicompartmental knee arthroplasty (UKA), benchmarked against accepted practice
  • Comparison of the effect of bupivacaine and prilocaine on postoperative outcomes for patients undergoing unicompartmental knee arthroplasty


ACHE: Arthroplasty Candidacy Help Engine

The ACHE tool will introduce standardised, evidence-based thresholds for hip and knee replacement surgery. It will be used in both primary and secondary care to determine a  patient's capacity to benefit from surgery and the cost-effectiveness of the treatment. 

Jonathan Cook and Sujin Kang

MSK-HQ: Arthritis Research UK MusculoSkeletal Health Questionnaire 

The MSK-HQ is being piloted and assessed for use across musculoskeletal care pathways, such as shoulder, hip, and knee joint surgery. Its measurement properties and the acceptability and feasibility of its routine use are being assessed.

Sujin Kang


BEST: Back Skills Training Trial

The BeST trial evaluated a cognitive behavioural intervention for lower back pain. It found that patients who received the BeST programme significantly reduced their disability and pain at 12 months and beyond. They reported significantly greater treatment satisfaction and improved quality of life. The programme is one of the most cost effective treatments available for the management of persistent low back pain to date.

This secondary analysis will perform categorisation using the Start back screening tool.

Bethan Copsey with RRIO

SARAH: Strengthening and Stretching for Rheumatoid Arthritis of the Hand

SARAH logoThe SARAH trial evaluated the effectiveness of a tailored exercise programme for hands and wrists for people with rheumatoid arthritis (RA) in addition to usual care. The trial showed that the individually tailored, progressive exercise programme, made up of a series of strengthening and stretching exercises, improved function and quality of life for patients with rheumatoid arthritis. The programme was also shown to be cost-effective, providing a low-cost intervention that can be adopted alongside regular medication.

A post hoc mediation analysis will be performed of the SARAH dataset.

Bethan Copsey with RRIO

Past and Projected Temporal Trends in Arthroscopic Hip Surgery

This project will describe the temporal trends in the adoption of hip arthroscopy in England between 2002 and 2013 and forecast trends for the next ten years

Gary Collins

Treatment of first-time traumatic anterior shoulder dislocation

The association between surgical treatment (compared to no surgery) and recurrence rates following a first episode of traumatic anterior shoulder dislocation amongst young adults will be studied. Clinical predictors of future dislocations in young adults with traumatic anterior shoulder dislocation will be investigated, stratified by whether surgery occurs or not.

Gary Collins and Sally Hopewell