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Clinical trials

BOSS: Barrett's Oesophagus Surveillance versus endoscopy at need Study

BOSS logoBOSS investigates whether regular endoscopic surveillance is better than endoscopy at need for detecting any early signs of oesophageal cancer in patients diagnosed with Barrett’s oesophagus.

Barrett's oesophagus is a complication of chronic gastro-oesophageal reflux disease, which is reflux of acidic fluid from the stomach into the oesophagus. The cells begin to grow abnormally, and can become cancerous.

Sharon Love and Corran Roberts

BRC-IBD: Oxford Biomedical research centre inflammatory bowel disease cohort

The Oxford Biomedical Research Centre has recruited a cohort of patients with inflammatory bowel disease (IBD). These patients have consented for their tissue to be biobanked and to be contacted for clinical studies. This project will use the BRC-IBD cohort to predict rescue therapies for IBD patients.

Sharon Love and Lei Clifton


One early sign of cancer is dysplasia, in which abnormal cells grow and cause an organ or tissue to enlarge. Lectins are a class of proteins that bind to carbohydrates. This study will investigate whether fluorescent lectins can be used to identify areas of dysplasia during endoscopy and surgery.

Susan Dutton and Karan Vadher

Other clinical research

Defining safe thresholds for the outpatient management of patients with acute upper gastrointestinal bleeding

This is a post hoc analysis of data collected during TRIGGER, a randomised trial. The data will be used to predict which patients that come to A&E with an upper gastrointestinal bleed can safely be sent home and which patients should be admitted to hospital.

Gary Collins