Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.


The DELTA2 guidance is available as a preprint:

Cook JA, Julious SA, Sones W, Hampson LV, Hewitt C, Berlin JA, Ashby D, Emsley R, Fergusson DA, Walters SJ, Wilson EC, Maclennan G, Stallard N, Rothwell JC, Bland M, Brown L, Ramsay CR, Cook A, Armstrong D, Altman D, Vale LD. Choosing the Target Difference ("effect size") for a Randomised Controlled Trial - DELTA2 Guidance. Preprints 2018, 2018080521.

The final DELTA2 guidance is anticipated to be published in the NIHR Health Technology Assessment Journal in early 2019.


The DELTA2 protocol has now been published and is freely available:

Cook JA, Julious SA, Sones W, Rothwell JC, Ramsay CR, Hampson LV, Emsley R, Walters SJ, Hewitt C, Bland MJ, Fergusson DA, Berlin J, Altman D, Vale LD. Choosing the target difference ("effect size") for a randomised controlled trial - DELTA2 guidance protocol. Trials. 2017; 18: 271.