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OBJECTIVE: To describe, explain and give practical suggestions regarding important principles and key methodological challenges in the study design, statistical analysis, and reporting of results from in vivo studies. CONCLUSIONS: Pre-specifying endpoints and analysis, recognizing the common underlying assumption of statistically independent observations, performing sample size calculations, and addressing multiplicity issues are important parts of an in vivo study. A clear reporting of results and informative graphical presentations of data are other important parts.

Original publication

DOI

10.1016/j.joca.2016.06.023

Type

Journal article

Journal

Osteoarthritis Cartilage

Publication Date

03/2017

Volume

25

Pages

364 - 368

Keywords

Analysis plan, Biostatistics, Experimental design, Inference, Results presentation, Study protocol