Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Researchers often analyze randomized trials and other comparative studies by separate analysis of changes from baseline in each parallel group. This may be the only analysis presented or it may be in addition to the direct comparison of allocated groups. We illustrate this by reference to 3 recently published nutritional trials. We show why this method of analysis may be highly misleading and may produce type I errors far greater than the 5% that we expect. We recommend direct comparison of means between groups with the use of baseline as a covariate if required.

Original publication

DOI

10.3945/ajcn.115.119768

Type

Journal article

Journal

Am J Clin Nutr

Publication Date

11/2015

Volume

102

Pages

991 - 994

Keywords

Guidelines as Topic, Humans, Nutritional Sciences, Randomized Controlled Trials as Topic, Statistics as Topic, United Kingdom