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News from the CSM, EQUATOR Network, and our collaborators

Moderate to high intensity exercise does not slow cognitive decline in people with dementia

Moderate to high intensity exercise does not slow cognitive decline in people with dementia

NDORMS Publication Research

Moderate to high intensity exercise does not slow cognitive (mental) impairment in older people with dementia, finds a trial published in the BMJ today.

Partial knee replacements better for many patients and cheaper for NHS

Partial knee replacements better for many patients and cheaper for NHS

Publication Research

Researchers at CSM and NDORMS have found that many more patients could be given a partial knee replacement instead of a total knee replacement, resulting in improvements in their quality of life and lower costs for the healthcare system.

CSM statisticians recognised at WCO-IOF-ESCEO conference

CSM statisticians recognised at WCO-IOF-ESCEO conference

Awards NDORMS Research

Three members of CSM were recognised for the excellence of their epidemiological research into osteoarthritis and musculoskeletal conditions at a conference this weekend.

‘Life support’ for livers may improve transplants

‘Life support’ for livers may improve transplants

NDORMS Research

Preserving livers at body temperature may improve transplant outcomes and increase viable donor liver numbers, thereby lowering waiting list mortality rates, reports a paper published online this week in Nature.

Sharing experiences in best-practice clinical trial design

Sharing experiences in best-practice clinical trial design

Adaptive trial designs Publication Research

CSM statisticians published their experiences in overcoming the challenges of using adaptive designs for early phase clinical trials. These trial designs are more likely to find the right answer than traditional designs.

CSM study protocol tied for winning position at ECCO workshop

CSM study protocol tied for winning position at ECCO workshop

Adaptive trial designs Awards Research

CSM collaborator Sean O’Cathail took CEDAR, an adaptive phase I trial in rectal cancer, to a Europe-wide protocol development workshop in June 2017, where it tied for most innovative protocol.

Showcasing five years of the Oxford Clinical Trials Research Unit

Showcasing five years of the Oxford Clinical Trials Research Unit

Research

The Oxford Clinical Trials Research Unit celebrates five years of running and supporting excellent clinical trials that benefit patients and improve healthcare.

Supporting patient safety through best-practice trial design

Supporting patient safety through best-practice trial design

Adaptive trial designs Publication Research

UK statisticians and trialists reach out to the clinical trial community in an awareness-raising paper published this week as a first step in changing practice. They promote the use of adaptive designs in early-phase clinical trials to improve trial efficiency, which will benefit patients.

Global experts adopt new guidelines for health data analysis

Global experts adopt new guidelines for health data analysis

EQUATOR Publication Research

Raising the bar in terms of research excellence - the best studies analysing public health data will soon get better.

Offering carers of people with dementia easily accessible support

Offering carers of people with dementia easily accessible support

Research

The UK’s largest research trial of support for carers of people with dementia, supported by CSM statisticians, has now launched nationally.

No study left behind: Reporting guidelines ensure all cancer research publications are usable

No study left behind: Reporting guidelines ensure all cancer research publications are usable

Research

To mark World Cancer Day this week, the EQUATOR Network’s Oncology Project, funded by Cancer Research UK, launches a new current awareness bulletin to help cancer researchers avoid research waste and report their work well.

SCALOP-2 trial: Investigating chemotherapy and radiotherapy in localised pancreatic cancer to improve outcomes

SCALOP-2 trial: Investigating chemotherapy and radiotherapy in localised pancreatic cancer to improve outcomes

Research

In commemoration of World Cancer Day on 4 February 2016, we are pleased to announce the opening of a new Cancer Research UK-funded pancreatic cancer trial supported by CSM statisticians.

Model-based trial design for more efficient phase I trials

Model-based trial design for more efficient phase I trials

Research

In commemoration of World Cancer Day on 4 February 2016, CSM statisticians present a TiTE-CRM phase I trial design for testing a chemoradiotherapy intervention in oesophageal cancer.

Improving diagnosis, monitoring and treatment of a precursor to oesophageal cancer

Improving diagnosis, monitoring and treatment of a precursor to oesophageal cancer

Research

In commemoration of World Cancer Day on 4 February 2016, read about two trials involving CSM statisticians on Barrett’s Oesophagus, a precursor to oesophageal cancer that affects over 500,000 UK patients.

#WeCanICan: Cancer research in CSM

#WeCanICan: Cancer research in CSM

Research

This week, we are celebrating how Oxford researchers are united in the fight against cancer.

New software from CSM ensures every trial participant counts

New software from CSM ensures every trial participant counts

Research

CSM statistician Peter Dutton has developed a software package that optimises the design of single-arm clinical trials in rare diseases.

A BOOST for lower back pain treatment

A BOOST for lower back pain treatment

Research

The Centre for Rehabilitation Research in Oxford (RRIO) led by Professor Sallie Lamb of NDORMS has been awarded £2 million by the National Institute for Health Research (NIHR) to look at improving the management of lower back pain in older people.

Clinical trial starts to test new treatment for Dupuytren’s disease

Clinical trial starts to test new treatment for Dupuytren’s disease

Research

A clinical trial to test a new treatment for Dupuytren’s disease has commenced at the Kennedy Institute and Botnar Research Centre. Affecting 4% of the UK population, this disease causes fingers to curl into the palm and can be extremely disabling.

New guidelines for reporting of clinical research to improve medical decision-making

New guidelines for reporting of clinical research to improve medical decision-making

Publication Research

New guidelines aiming to improve tools used by doctors in making diagnoses and treatment decisions are published today in the Annals of Internal Medicine and 10 other journals.

New Rehabilitation Trial is a CORKA

Research

Work on the CORKA trial - Community-based Rehabilitation after Knee Arthroplasty - has officially started, led Dr Karen Barker, of NDORMS.